Monica Metea 7/25/26 Monica Metea 7/25/26

Measuring the Rewiring: Connectivity Biomarkers for the Next Generation of Psychiatric Drugs

For pharma teams developing neuroplastogens, from psychedelics to next-generation antidepressants, this piece lays out brain functional connectivity, obtained from EEG or fMRI, as the key biomarker for showing that a drug is reorganizing brain circuits. It covers how Lucerum's standardized qEEG methods turn connectivity into a practical, dose-tracked measure usable across every clinical trial phase, with examples from a real MDD program showing the approach in action, from healthy volunteers through patient outcomes.

Monica Metea 7/6/26 Monica Metea 7/6/26

Quantitative EEG in Depression: Predictors of Treatment Response

Quantitative EEG in Depression: Predictors of Treatment Response

Antidepressants and rTMS help roughly half of the patients who try them. Nobody knows which half in advance. That's a solvable problem — and quantitative EEG has quietly spent forty years solving it.

In this piece I give a broad overview of where the field actually is: the early generation of qEEG response predictors that have survived four decades of scrutiny and meta-analysis, the shift now underway toward network- and connectome-based markers that match the modern view of depression as a circuit-level disorder, and the emerging frontier of source-localized, neurotransmitter-informed EEG that could turn precision psychopharmacology from an aspiration into a workflow. I close on where things stand with the FDA and payers, and why the momentum is finally moving in the right direction.

qEEG is not a miracle. But the comparison is not qEEG-versus-perfection — it's versus-the-coin-flip. #qEEG, #Neuroscience, #BrainMapping, #Depression, #Psychiatry, #rTMS, #Antidepressants, #Psychopharmacology, #Connectomics

Monica Metea 6/26/26 Monica Metea 6/26/26

Personalizing TMS with qEEG guidance: Two Ways to Stop Guessing Where to Stimulate

Most TMS treatments still place the coil based on scalp landmarks — a pragmatic approach that has served the field well but leaves significant individual variability unaddressed. We now have better tools. Two data sources generate from EEG can tell you precisely where to aim and what to do when you get there: current source density (CSD) from qEEG and functional connectivity maps. Here's how each works, and how to combine them and where to find the precision tools needed for personalized TMS.